Systems pharmacology to investigate the interaction of berberine and other drugs in treating polycystic ovary syndrome
نویسندگان
چکیده
Polycystic ovary syndrome (PCOS) is a common multifactorial endocrine disorder among women of childbearing age. PCOS has various and heterogeneous clinical features apart from its indefinite pathogenesis and mechanism. Clinical drugs for PCOS are multifarious because it only treats separate symptoms. Berberine is an isoquinoline plant alkaloid with numerous biological activities, and it was testified to improve some diseases related to PCOS in animal models and in humans. Systems pharmacology was utilized to predict the potential targets of berberine related to PCOS and the potential drug-drug interaction base on the disease network. In conclusion, berberine is a promising polypharmacological drug for treating PCOS, and for enhancing the efficacy of clinical drugs.
منابع مشابه
Effect of Berberine on the Levels of Sex Hormones in Polycystic Ovary Syndrome-Induced by Letrozole in Adult Female Wistar Rats
Background and Objectives: Berberine is a yellow alkaloid, which is found in root, rhizome, skin, and stem of many plants, including barberry, turmeric, and poppy. Berberine has anti-inflammatory, anti-bacterial, and anti-viral properties. In the present study, the protective effect of berberine on letrozole-induced Polycystic Ovary Syndrome (PCOS), was investigated in adult female Wistar rats....
متن کاملSurvey on the interaction effect of dopamine D2 receptor antagonist on morphine-induced polycystic ovary syndrome in rat
Background and Objective: Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic disorders in premenopausal women. Opioid drugs, including morphine are effective inducers of the PCOS. Hyperprolactinemia also increases the likelihood of this complication. The dopamine, the inhibitor of prolactin secretion, has receptors in the ovarian tissue. In this study, metoclopra...
متن کاملP-192: Association of Cytochrome P450 2D6 (CYP2D6) Gene Polymorphism with Clomiphene Citrate Treatment in Iranian Infertile Women with Polycystic Ovary Syndrome
Background: Clomiphene Citrate (CC) is the most frequently administered drug for the treatment of female infertility [e.g. polycystic ovary syndrome (PCOS)]; which aims at restoring ovulation. Clomiphene is metabolized by CYP2D6, an important enzyme responsible for the metabolism of approximately 25% of clinically used drugs. CYP2D6 is very polymorphic and thought to result in inter- individual...
متن کاملPnm-5: Midwifery Intensive Cares in Polycystic Ovary Syndrome
Background: Polycystic ovary syndrome is a common endocrine disorder with 3-7% prevalence in the general population and 10% in women of childbearing. This rate has increased in infertile women. The main composition of this syndrome includes anovulation or olygoovulation, clinical and laboratory signs of increased androgens and observation polycystic ovaries on ultrasound in evaluation. In this ...
متن کاملHerbal Medicine in the Treatment of Polycystic Ovary Syndrome
Polycystic Ovary Syndrome (PCOS) is a hormonal disorder that affects between 5 - 10% of women who are of reproductive age. The most common symptoms of PCOS are obesity/difficulty losing weight, acne, amenorrhea (absence of menstrual cycles), irregular menstrual cycles, hirsutism (increased growth of corporal hair), insulin resistance, and high cholesterol. One of the treatments for PCOS is the ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 6 شماره
صفحات -
تاریخ انتشار 2016